专家信息

漆淑华

漆淑华 研究专家

职务:中科院海洋微生物中心副主任,博士生导师

所在单位:中国科学院南海海洋研究所

专长领域:海洋天然药物化学与海洋化学生态学

个人简介:

简历:

漆淑华,女,博士,现于中国科学院南海海洋研究所任职责任研究员、博士生导师,曾于中国科学院昆明植物研究所植物化学国家重点实验室获博士学位,香港科技大学做博士后,加拿大不列颠哥伦比亚大学做高级访问学者。目前主要从事海洋天然药物化学与海洋化学生态学领域的研究,主要研究兴趣是从海洋动植物和微生物中寻找有药用开发前景的活性先导化合物、以及具有重要生态功能的小分子化合物。已从多种药用植物、南海柳珊瑚、海藻和海洋微生物中分离鉴定了500多个单体化合物,其中包括90多个新化合物,筛选到多个具有强抗肿瘤、或抗病毒药用活性先导化合物、以及几十个具有强抗菌、昆虫拒食性、抗海洋生物污损活性小分子化合物。主持了国家863计划、国家自然科学基金等10多项国家、省部级科研项目;近年来发表了60多篇研究论文,其中40多篇国际SCI论文,做为第一发明人申请了9项国家发明专利(已获授权5项),参与编写两部专著,参与获2007年国家科技进步二等奖和2004年海南省科技进步特等奖各一项,已培养多名博士和硕士研究生。联系电话:020-89022112;E-mail:shuhuaqi@scsio.ac.cn,shuhuaqi2001@yahoo.com。

获奖及荣誉:

2007年国家科技进步二等奖,排名第五。 2004年海南省科技进步特等奖,排名第四

代表论著:

1. Shu-Hua Qi, Cheng-Hai Gao, Pei-Yuan Qian, Si Zhang. Steroids from the South China Sea gorgonian Subergorgia suberosa. Nat Prod Commun. 2010, 5(2): 201-204.

2. Shu-Hua Qi, Li Miao, Ying Xu, Si Zhang. Steroids and alkaloids from the gorgonian Isis minorbrachyblasta: Structures, cytotoxicity and antilarval activity. Helve. Chim. Acta. 2010, 93: 511-516.

3. Shu-Hua Qi, Si Zhang. Steroids and Alkaloids from the South China Sea sponge Axinella sp. Journal of Asian Natural Products Research, 2009, 11(12): 1040-1044.

4. Shu-Hua Qi, Guo-Chen Su, Yi-Fei Wang, Qiu-Ying Liu, Cheng-Hai Gao. Alkaloids from the South China Sea black coral Antipathes dichotoma. Chem. Pharm. Bull. 2009, 57(1): 87-88.

5. Shu-Hua Qi, Ying Xu, Hai-Rong Xiong, Pei-Yuan Qian, Si Zhang. Antifouling and Antibacterial Compounds from a Marine Fungus Cladosporium sp. F14. World Journal of Microbiology and Biotechnology 2009, 25(3): 399-406.

6. Shu-Hua Qi, Si Zhang, Bei-Yuan Qian. Antifeedant and antifouling briaranes from the South China Sea gorgonian Junceella juncea. Chemistry of Natural Compounds 2009, 45(1): 49-54.

7. Shu-Hua Qi, Ying Xu, Hai-Rong Xiong, Pei-Yuan Qian, Si Zhang. Antibacterial and antilarval compounds from marine bacterium Pseudomonas rhizosphaerae. Annals of Microbiology, 2009, 59 (2) 229-233.

8. Shu-Hua Qi, Si Zhang, Hui Huang. Four purine alkaloids from the South China Sea gorgonian Subergorgia suberosa. J. Nat. Prod. 2008, 71(4):716-718.

9. Shu-Hua Qi, Si Zhang, Bei-Yuan Qian. Antifouling and Antibacterial Compounds of the the South China Sea Gorgonians Subergorgia suberosa and Scripearia gracillis. Nat. Prod. Res. 2008, 22(2): 514-166.

10. Shu-Hua Qi, Si Zhang, Bei-Yuan Qian. Antifeedant, antibacterial and antilarval active secondary metabolites from seagrass Enhalus acoroides. Botan. Mar. 2008, 51: 441-447.

11. Shu-Hua Qi, Si Zhang, Yi-Fei Wang. Complete 1H and 13C NMR assignments of three new polyhydroxylated sterols from the South China Sea gorgonian Subergorgia suberosa. Magn.Res.Chem. 2007, 45(12): 1088-1091.

12. Shu-Hua Qi, Si Zhang, Bei-Yuan Qian, Zhi-Hui Xiao, Ming-Yi Li. Ten new antifouling briarane diterpenoids from the South China Sea gorgonian Junceella juncea. Tetrahedron 2006, 62: 9123-9130.

13. Shu-Hua Qi, Si Zhang, Xiang Li, Zhi-Hui Xiao. A New Cytotoxic Sesquiterpene-Alkaloid from the South China Sea gorgonian Subergorgia suberosa. J. Nat.Prod. 2005, 68: 1288 –1289。

14. Shu-Hua Qi, Si Zhang, Zhi-Hui Xiao. New Briaranes from the South China Sea Gorgonian Junceella fragilis. Helve. Chim. Acta. 2005, 88(8): 2349-2354.

15. Shu-Hua Qi, Si Zhang, Zhi-Hui Xiao, Jian-She Huang. Complete 1H and 13C NMR assignments of four new steroidal glycosides from a gorgonian coral Junceella juncea. Magn. Res. Chem. 2005, 43(3): 266-268.

16. Shu-Hua Qi, Si Zhang, Zhi-Hui Xiao, Jian-She Huang. New Briaranes from the South China Sea Gorgonian Junceella juncea. J. Nat. Prod. 2004, 67(11): 1907-1910.

17. Shu-Hua Qi, Si Zhang, Jian-She Huang, Zhi-Hui Xiao. Study on the Chemical Constituents of the South China Sea gorgonian Junceella juncea. Chem. Pharm. Bull. 2004, 52 (12): 1476-1478.

18. Shu-Hua Qi, Si Zhang, Jian-She Huang, Zhi-Hui Xiao, Jun Wu. Glycerol Derivatives and Sterols from Sargassum parvivesiculosum. Chem. Pharm. Bull., 2004, 52(8): 986-988.

19. Shu-Hua Qi, Li Chen, Xiao-Dong Luo. Novel Tetranortriterpenoid    Derivatives from Munronia henryi. Tetrahedron 2003, 59: 4193-4199.

20. Shu-Hua Qi, Da-Gang Wu, Li Chen, Yun-Bao Ma, Xiao-Dong Luo. Insect Antifeedants from Munronia henryi: Structure of Munroniamide, J. Agric. Food Chem. 2003, 51: 6949-6952.

21. Shu-Hua Qi, Da-Gang Wu, Yun-Bao Ma, Xiao-Dong Luo, A New Tetranortriterpenoid from Dysoxylum lenticellatum. Z. Naturforsch. 2003, 58b: 1128-1132.

22. Shu-Hua Qi, Da-Gang Wu, Yun-Bao Ma, Xiao-Dong Luo. Chemical Constituents of Ailanthus triphys (leaves). Chinese Journal of Chemistry. 2003, 21(2): 200-203.

23. Shu-Hua Qi, Da-Gang Wu, Yun-Bao Ma, Xiao-Dong Luo. The Chemical Constituents of Munronia henryi. Journal of Asian Natural Products Research 2003, 5(3): 215-221.

24. Shu-Hua Qi, Da-Gang Wu, Yun-Bao Ma, Xiao-Dong Luo. A new flavane from Carapa guianensis Aubl. (Meliaceae). Acta Botanica Sinica 2003, 45(9): 1129-1133.

25. Shu-Hua Qi, Da-Gang Wu, Si Zhang, Xiao-Dong Luo. Constituents of Carapa guianensis Aubl.( Meliaceae). Pharmacies 2004, 59(6): 488-490.

26. Cheng-Hai Gao,Xin-Peng Tian, Shu-Hua Qi*, Xiong-Ming Luo, Ping Wang, Si Zhang. Antibacterial and antilarval compounds from marine gorgonian-associated bacterium Bacillus amyloliquefaciens SCSIO 00856. The Journal of Antibiotics. 2010, 63: 191-193.

27. Cheng-Hai Gao, Xu-Hua Nong, Shu-Hua Qi*, Xiong-Ming Luo, Si Zhang, Hai-Rong Xiong. A new nine-membered lactone from a marine fungus Cladosporium sp. F14. Chinese Chemical Letters,2010, in press.

28. Jin Yang, Shu-Hua Qi, Si Zhang. Three Polyoxygenated Steroids from the South China Sea Gorgonian Coral Subergorgia reticulate, Chinese Journal of Chemistry 2005, 23: 1218-1222.

29. Yun-Qi Qiu, Shu-Hua Qi, Si Zhang. New Polyoxygenated Steroids from the South China Sea Gorgonian Echinogorgia aurantiaca, Pharmazie 2006, 6: 645-647.

30. Jin Yang, Shu-Hua Qi, Si Zhang. Bebrycoside, a new steroidal glycoside from the Chinese gorgonian coral Bebryce indica. Pharmazie 2007, 62(2): 154-155.

31. Yun-Qi Qiu, Shu-Hua Qi, Si Zhang. Thiophene Derivatives From the Ariel Part of Pluchea indica.  Heterocycles 2008, 75(7): 1757-1764.

32. Guang-Chun Gao, Shu-Hua Qi, Si Zhang. Phenolic compounds and iridoids from the stem bark of Chinese mangrove associate Catunaregam spinosa. Pharmazie 2008, 63(7):542-544.

33. Xiong-Ming Luo, Shu-Hua Qi, Hao Yin, Cheng-Hai Gao, Si Zhang. Alkaloids from the Stem Bark of Micromelum falcatum. Chem. Pharm. Bull. 2009, 57(6): 600-6.

34. Xiong-ming Luo, Shu-hua Qi, Hao Yin, Zhi-hui Xiao, Si Zhang. Micromelosides A-D, four new coumarins from the stem bark of Micromelum falcatum. Magnetic resonance in chemistry 2009,47(12):1110-1114.

35. Jin Yang, Si Zhang, Shu-Hua Qi. Briarane-type diterpenoids from the China gorgonian coral Subergorgia reticulate. Biochemical Systematics and Ecology 2007, 35: 770-773.

承担科研项目情况:

1.国家863计划专题课题,负责人,热带柳珊瑚和海草中活性先导化合物的发现与结构优化,2007-2010年。

2.国家973计划重要科学前沿领域项目,子课题负责人之一,海洋微生物次生代谢的生理生态效应及其生物合成机制,2009-2014年。

3.国家自然科学基金项目,来源于两种南海海草的高效低毒海洋防污剂的研究,2010-2012年。

4.国家自然科学基金项目,南海两种药用黑角珊瑚中抗肿瘤活性成分及其作用机制的研究,2009-2011年。

5.国家自然科学基金与香港研资局联合项目,来源于海洋微生物的丁烯酸内酯和吲哚生物碱两类抗污损活性化合物的构效关系与作用机制(基因和蛋白水平)的研究,2010-2012年。

6.国家自然科学基金项目,南海侧扁软柳珊瑚中抗癌活性成分的研究,2006-2008年。

7.广东省自然科学基金,负责人,南海柳珊瑚和海草中低毒抗生物污损物质的发现,2009-2011。

8.广东省科技计划项目,负责人,南海柳珊瑚中抗肿瘤活性成分的研究,2008-2010年。

9.广州市重大科技专项,课题负责人,抗病毒候选药物黄酮苷HCTHF的研究,2009-2011年。

10.广东省自然科学基金,负责人,南海海菖蒲中杀虫活性成分的研究,2006-2007年。

12.中科院重要方向性项目,课题负责人,热带海洋微生物活性化合物的研究,2007-2009年。

11.广东省基金团队项目,核心团队成员,南海生物活性先导化合物及其创新药物研究与开发,2004-2007年。

主要奖项:

2007年国家科技进步二等奖,排名第五。 2004年海南省科技进步特等奖,排名第四

广州市新港西路164号 020-89022112 shuhuaqi@scsio.ac.cn,shuhuaqi2001@yahoo.com

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